Kidney

Home Page »
Research »
Kidney

Kidney

Minimally invasive techniques, such as thermal ablation, are increasingly being employed in an attempt to decrease morbidity and preserve renal function in patients with primary kidney cancer. Low frequency radiofrequency (RF) ablation is effective for small (< 3 cm) and more peripheral tumors, but the risk of treatment failure is higher for larger or centrally located tumors. 2.45GHz antenna have been shown to be superior to for heating kidney tissue¹:

2.45GHz are well suited to heating kidney tissue: Kidneys have a high water content, which leads to increased heat generation with a high frequency, 2.45GHz.
Faster heating to higher temperatures: Higher tissue temperatures and faster heat generation during 2.45 GHz ablation translate to larger ablation zones and an increased ability to overcome cooling from blood vessels.
Larger ablation zones: 2.45GHz probes create larger volumes of ablation when compared with lower RF, which may translate to more reliable treatment of larger tumors. In addition, the invasiveness of the procedure may be decreased because fewer 2.45GHz antenna placements are needed to treat a given volume of tissue.

References:

1. Brace CL, Laeseke PF, Sampson LA, Frey TM, van der Weide DW, Lee FT Jr. Microwave ablation with a single small-gauge triaxial antenna: in vivo porcine liver model. Radiology. 2007 Feb;242(2):435-40.

2. Brace CL, Laeseke PF, Sampson LA, Frey TM, van der Weide DW, Lee FT Jr. Microwave ablation with small-gauge triaxial antennas: Multiple simultaneously-powered antennas create large volumes of ablation in vivo. Radiology. 2007 July;244(1)151-6.

3. Laeseke PF, Lee FT Jr, van der Weide DW, Brace CL. Multiple-Antenna Microwave Ablation: Spatially Distributing Power Improves Thermal Profiles and Reduces Invasiveness. Journal of Interventional Oncology, in press.

4. Wright AS, Lee FT Jr, Mahvi DM. Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis. Ann Surg Oncol. 2003 Apr;10(3):275-83.

5. Wright AS, Sampson LA, Warner TF, Mahvi DM, Lee FT Jr. Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology. 2005 Jul;236(1):132-9.

6. Yu NC, Raman SS, Kim YJ, Lassman C, Chang X, Lu DS. Microwave liver ablation: influence of hepatic vein size on heat-sink effect in a porcine model. J Vasc Interv Radiol. 2008 Jul;19(7):1087-92.

7. Brace CL, Hinshaw JL, Laeseke PF, Diaz TA, Sampson LA, Lee FT Jr. Pulmonary thermal ablation: Comparing radiofrequency and microwave devices using gross pathology and CT imaging. Radiology, 2009 March 31.

8. Durick NA, Laeseke PF, Broderick LS, Lee FT Jr, Sampson LA, Frey TM, Warner TF, Fine JP, van der Weide DW, Brace CL. Microwave Ablation with Triaxial Antennas Tuned for Lung: Results in an in vivo Porcine Model. Radiology. 2008;247 80-87.